Tumor-Derived Exosomes in Tumor-Induced Immune Suppression

International Journal of Molecular Sciences

Qiongyu Hao¹  Yanyuan Wu¹  Jaydutt V. Vadgama¹  Piwen Wang¹  Yong Wu¹ 

[1] Division of Cancer Research and Training, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA;

关键词: tumor-derived exosomes;    tumor microenvironment;    immune suppression;   

DOI  :  10.3390/ijms23031461

来源: DOAJ

【 摘 要 】

Exosomes are a class of small membrane-bound extracellular vesicles released by almost all cell types and present in all body fluids. Based on the studies of exosome content and their interactions with recipient cells, exosomes are now thought to mediate “targeted” information transfer. Tumor-derived exosomes (TEX) carry a cargo of molecules different from that of normal cell-derived exosomes. TEX functions to mediate distinct biological effects such as receptor discharge and intercellular cross-talk. The immune system defenses, which may initially restrict tumor progression, are progressively blunted by the broad array of TEX molecules that activate suppressive pathways in different immune cells. Herein, we provide a review of the latest research progress on TEX in the context of tumor-mediated immune suppression and discuss the potential as well as challenges of TEX as a target of immunotherapy.

【 授权许可】

Unknown