Influence of Trace Elements on Neurodegenerative Diseases of The Eye—The Glaucoma Model

International Journal of Molecular Sciences

Robert Rejdak¹  Rosario Amato²  GiovanniLuca Romano³  Claudio Bucolo³  Filippo Drago³  Teresio Avitabile⁴  Sandrine Zweifel⁵  Anahita Bajka⁵  Agnieszka Kamińska⁶  MarioDamiano Toro⁶  Magdalena Rejdak⁷  Michal Fiedorowicz⁸ 

[1] Chair and Department of General and Pediatric Ophthalmology, Medical University of Lublin, 20-079 Lublin, Poland;Department of Biology, University of Pisa, 56126 Pisa, Italy;Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy;Department of Ophthalmology, University of Catania, 95123 Catania, Italy;Department of Ophthalmology, University of Zurich, 8091 Zurich, Switzerland;Faculty of Medical Sciences, Collegium Medicum, Cardinal Stefan Wyszyński University, 01-815 Warsaw, Poland;Medical University of Warsaw, 02-106 Warsaw, Poland;Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, Poland;

关键词: glaucoma;    neurodegenerative disease;    iron;    copper;    zinc;    selenium;   

DOI  :  10.3390/ijms22094323

来源: DOAJ

【 摘 要 】

Glaucoma is a heterogeneous group of chronic neurodegenerative disorders characterized by a relatively selective, progressive damage to the retinal ganglion cells (RGCs) and their axons, which leads to axon loss and visual field alterations. To date, many studies have shown the role of various elements, mainly metals, in maintaining the balance of prooxidative and antioxidative processes, regulation of fluid and ion flow through cell membranes of the ocular tissues. Based on the earlier and current research results, their relationship with the development and progression of glaucoma seems obvious and is increasingly appreciated. In this review, we aimed to summarize the current evidence on the role of trace elements in the pathogenesis and prevention of glaucomatous diseases. Special attention is also paid to the genetic background associated with glaucoma-related abnormalities of physiological processes that regulate or involve the ions of elements considered as trace elements necessary for the functioning of the cells.

【 授权许可】

Unknown