Thalamic deep brain stimulation for Tourette Syndrome: A naturalistic trial with brief randomized, double-blinded sham-controlled periods

Brain Stimulation

Thomas Schüller¹  Pablo Andrade²  Lars Timmermann³  Jens Kuhn³  Veerle Visser-Vandewalle⁴  Martin Hellmich⁵  Juan Carlos Baldermann⁶  Michael T. Barbe⁶  Sophia Schleyken⁷  Reinhild Prinz-Langenohl⁷  Sina Kohl⁷  Daniel Huys⁸ 

[1] Corresponding author. University Hospital Cologne, Kerpener Straße 62, 50937, Cologne, Germany.;Department of Psychiatry, Psychotherapy, and Psychosomatics, Johanniter Hospital Oberhausen, Oberhausen, Germany;University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Psychiatry and Psychotherapy, Cologne, Germany;University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinical Trials Centre, Cologne, Germany;University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Functional Neurosurgery and Stereotaxy, Cologne, Germany;University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, Cologne, Germany;University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Psychiatry and Psychotherapy, Cologne, Germany;University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Medical Statistics and Computational Biology, Cologne, Germany;

关键词: Tourette syndrome;    Tic disorders;    Deep brain stimulation;    DBS;    Clinical trial;    Thalamus;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: There is still a lack of controlled studies to prove efficacy of thalamic deep brain stimulation for Tourette's Syndrome. Objectives: In this controlled trial, we investigated the course of tic severity, comorbidities and quality of life during thalamic stimulation and whether changes in tic severity can be assigned to ongoing compared to sham stimulation. Methods: We included eight adult patients with medically refractory Tourette's syndrome. Bilateral electrodes were implanted in the centromedian-parafascicular-complex and the nucleus ventro-oralis internus. Tic severity, quality of life and comorbidities were assessed before surgery as well as six and twelve months after. Short randomized, double-blinded sham-controlled crossover sequences with either active or sham stimulation were implemented at both six- and twelve-months’ assessments. The primary outcome measurement was the difference in the Yale Global Tic Severity Scale tic score between active and sham stimulation. Adverse events were systematically surveyed for all patients to evaluate safety. Results: Active stimulation resulted in significantly higher tic reductions than sham stimulation (F = 79.5; p = 0.001). Overall quality of life and comorbidities improved significantly in the open-label-phase. Over the course of the trial two severe adverse events occurred that were resolved without sequelae. Conclusion: Our results provide evidence that thalamic stimulation is effective in improving tic severity and overall quality of life. Crucially, the reduction of tic severity was primarily driven by active stimulation. Further research may focus on improving stimulation protocols and refining patient selection to improve efficacy and safety of deep brain stimulation for Tourette's Syndrome.

【 授权许可】

Unknown