Brain Plasticity in Humans and Model Systems: Advances, Challenges, and Future Directions

International Journal of Molecular Sciences

Christine J. Charvet¹  Luca Bonfanti² 

[1] Center for Neuroscience, Delaware State University, Dover, DE 19901, USA;Department of Veterinary Sciences, University of Turin, Largo Braccini 2, 10095 Grugliasco, TO, Italy;

关键词: neurogenesis;    immature neurons;    translating time;    mammals;    doublecortin;    PSA-NCAM;   

DOI  :  10.3390/ijms22179358

来源: DOAJ

【 摘 要 】

Plasticity, and in particular, neurogenesis, is a promising target to treat and prevent a wide variety of diseases (e.g., epilepsy, stroke, dementia). There are different types of plasticity, which vary with age, brain region, and species. These observations stress the importance of defining plasticity along temporal and spatial dimensions. We review recent studies focused on brain plasticity across the lifespan and in different species. One main theme to emerge from this work is that plasticity declines with age but that we have yet to map these different forms of plasticity across species. As part of this effort, we discuss our recent progress aimed to identify corresponding ages across species, and how this information can be used to map temporal variation in plasticity from model systems to humans.

【 授权许可】

Unknown