Genomic Profiles of a Patient of Pulmonary Hepatoid Adenocarcinoma With High AFP Level: A Case Report

Frontiers in Oncology

Jing Zhao¹  Hongjun Gao¹  Xiaoqing Liu¹  Jinglin Li¹  Xiya Ma¹  Bingxin Xu²  Huiwei Qi² 

[1] Department of Pulmonary Oncology, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China;Shanghai Tongshu Biotechnology Co., Ltd., Shanghai, China;

关键词: hepatoid adenocarcinoma of lung;    α-fetoprotein;    FAT atypical cadherin 1;    genomic profiles;    immunotherapy;   

DOI  :  10.3389/fonc.2019.01360

来源: DOAJ

【 摘 要 】

Hepatoid adenocarcinoma of lung (HAL) is a rare and aggressive tumor. The current study reported a new HAL case in the right lower lung with high serum α-fetoprotein (AFP) level in a 71-year-old male patient. After the confirmation of morphology and immunohistochemistry, the patient was diagnosed clinically with HAL and treated with radio-frequency ablation. However, the patient whose disease progressed eventually died 4 months after diagnosis. Whole genome sequencing analysis identified a driver gene mutation in the FAT atypical cadherin 1 gene (FAT1) and the copy number loss. The tumor was microsatellite-stable and tumor mutation burden (TMB) was 1.69 mutations/Mb. PD-L1 expression was negative by IHC. Our finding provide further clues for the molecular basis of HAL and the efficacy of immunotherapy needs to be explored.

【 授权许可】

Unknown