Lindgomycin, an Unusual Antibiotic Polyketide from a Marine Fungus of the Lindgomycetaceae

Marine Drugs

Jutta Wiese¹  Johannes F. Imhoff¹  Antje Labes¹  Annemarie Kramer¹  Rolf Schmaljohann¹  Bin Wu¹ 

[1] GEOMAR Helmholtz Centre for Ocean Research Kiel, 24105 Kiel, Germany;

关键词: marine fungi;    lindgomycin;    antibiotic;    MRSA;    marine natural products;   

DOI  :  10.3390/md13084617

来源: DOAJ

【 摘 要 】

An unusual polyketide with a new carbon skeleton, lindgomycin (1), and the recently described ascosetin (2) were extracted from mycelia and culture broth of different Lindgomycetaceae strains, which were isolated from a sponge of the Kiel Fjord in the Baltic Sea (Germany) and from the Antarctic. Their structures were established by spectroscopic means.In the new polyketide, two distinct domains, a bicyclic hydrocarbon and a tetramic acid,are connected by a bridging carbonyl. The tetramic acid substructure of compound 1was proved to possess a unique 5-benzylpyrrolidine-2,4-dione unit. The combination of5-benzylpyrrolidine-2,4-dione of compound 1 in its tetramic acid half and 3-methylbut-3-enoic acid pendant in its decalin half allow the assignment of a new carbon skeleton. The new compound 1 and ascosetin showed antibiotic activities with IC50 value of 5.1 (±0.2) µM and 3.2 (±0.4) μM, respectively, against methicillin-resistant Staphylococcus aureus.

【 授权许可】

Unknown