Anti-Skin-Aging Activity of a Standardized Extract from Panax ginseng Leaves In Vitro and In Human Volunteer

Cosmetics

Jung-A Lee¹  Seoungwoo Shin¹  Deokhoon Park¹  Dahee Son¹  Eunsun Jung¹ 

[1] Biospectrum Life Science Institute, U-TOWER 18th FL, 767, Sinsu Ro, Suji Gu, Yongin City, Gyunggi Do 16827, Korea;

关键词: Panax ginseng leaf;    ginsenoside Rb3;    collagen synthesis;    anti-wrinkle;   

DOI  :  10.3390/cosmetics4020018

来源: DOAJ

【 摘 要 】

Ginseng leaves contain high saponin composition and content, but are used less often than the root part. To develop a use for the leaves that exploits their properties, we studied ginseng leaves as the raw material of anti-aging cosmetics. This study highlights an assessment of the cellular factivity and clinical efficacy of ginseng leaf extract, providing necessary information relevant to the development of new cosmetic products. Panax ginseng leaf purified extracts (PGLE) were shown to have high contents of Rb3 and Rb2. Rb3, the major chemical components of PGLE, promoted collagen synthesis though the activation of transforming growth factor-β (TGF-β) in human skin fibroblast cells. In addition, the possibility of PGLE as an anti-skin-aging agent has also been clinically validated. Our analysis of the crow’s feet wrinkle showed that there was a decrease in the depth of deep furrows in the region of interest (RI) treated with PGLE lotion over an eight-week period. Based on these results, we suggest the possibility that PGLE, having high levels of Rb3, be considered as an attractive, wrinkle-reducing candidate for topical application.

【 授权许可】

Unknown