Peroneal nerve reconstruction by using glycerol-preserved veins: histological and functional assessment in rats

Acta Cirúrgica Brasileira

Ciro Ferreira Da Silva¹  Marcio Paulino Costa¹ 

[1] Universidade de São Paulo;

关键词: Peroneal Nerve;    Peripheral Nerves;    Nerve Regeneration;    Reconstructive Surgical Procedures;    Glycerol;    Blood Vessels;    Transplantation, Homologous;    Rats;   

DOI  :  10.1590/S0102-86502013000200002

来源: DOAJ

【 摘 要 】

PURPOSE: To compare the degree of neural regeneration in rats upon interposition of autologous nerve graft, autogenous vein, glycerol-preserved autogenous vein, and glycerol-preserved allogeneic vein using qualitative and quantitative histological analyses as well as functional assessments. METHODS: Peroneal nerves were reconstructed differently in four groups of animals. Functional assessments were performed pre- and postoperatively for a period of six weeks. After six weeks, the animals were sacrificed and histological evaluations were performed. RESULTS: Histological patterns of autogenous veins without preservation showed pronounced neoangiogenesis and extensive axonal rarefaction, as confirmed by axonal counting and functional assessments. Glycerol-preserved veins had results similar to the control. CONCLUSIONS: Glycerol-preserved autogenous or allogeneic veins showed similar results to autograft results. The autogenous vein (without preservation in glycerol) presented histological and functional outcomes statistically lower than other groups.

【 授权许可】

Unknown