PCL-ZnO/TiO2/HAp Electrospun Composite Fibers with Applications in Tissue Engineering

Polymers

Georgeta Voicu¹  Sorin-Ion Jinga¹  Cristina Busuioc¹  Andreea-Ioana Zamfirescu¹  Monica Enculescu²  Alexandru Evanghelidis² 

[1] Department of Science and Engineering of Oxide Materials and Nanomaterials, Politehnica University of Bucharest, RO-011061 Bucharest, Romania;Laboratory of Multifunctional Materials and Structures, National Institute of Materials Physics, RO-077125 Magurele, Romania;

关键词: fibers;    composites;    scaffolds;    electrospinning;    tissue engineering;   

DOI  :  10.3390/polym11111793

来源: DOAJ

【 摘 要 】

The main objective of the tissue engineering field is to regenerate the damaged parts of the body by developing biological substitutes that maintain, restore, or improve original tissue function. In this context, by using the electrospinning technique, composite scaffolds based on polycaprolactone (PCL) and inorganic powders were successfully obtained, namely: zinc oxide (ZnO), titanium dioxide (TiO₂) and hydroxyapatite (HAp). The novelty of this approach consists in the production of fibrous membranes based on a biodegradable polymer and loaded with different types of mineral powders, each of them having a particular function in the resulting composite. Subsequently, the precursor powders and the resulting composite materials were characterized by the structural and morphological point of view in order to determine their applicability in the field of bone regeneration. The biological assays demonstrated that the obtained scaffolds represent support that is accepted by the cell cultures. Through simulated body fluid immersion, the biodegradability of the composites was highlighted, with fiber fragmentation and surface degradation within the testing period.

【 授权许可】

Unknown