Evolving therapy of adult acute lymphoblastic leukemia: state-of-the-art treatment and future directions

Journal of Hematology & Oncology

Hagop Kantarjian¹  Nicholas J. Short¹  Elias Jabbour¹  Bachar Samra¹  Farhad Ravandi¹ 

[1] Department of Leukemia, The University of Texas MD Anderson Cancer Center;

关键词: Acute lymphoblastic leukemia;    Monoclonal antibody;    Inotuzumab ozogamicin;    Blinatumomab;    Chimeric antigen receptor;   

DOI  :  10.1186/s13045-020-00905-2

来源: DOAJ

【 摘 要 】

Abstract Recent years have witnessed major advances that have improved outcome of adults with acute lymphoblastic leukemia (ALL). The emergence of the concept of measurable residual disease has fine-tuned our prognostic models and guided our treatment decisions. The treatment paradigms of ALL have been revolutionized with the advent of tyrosine kinase inhibitors targeting BCR-ABL1, monoclonal antibodies targeting CD20 (rituximab), antibody-drug conjugates targeting CD22 (inotuzumab ozogamicin), bispecific antibodies (blinatumomab), and CD19 chimeric antigen receptor T cell therapy (tisagenlecleucel). These highly effective new agents are allowing for novel approaches that reduce reliance on intensive cytotoxic chemotherapy and hematopoietic stem cell transplantation in first remission. This comprehensive review will focus on the recent advances and future directions in novel therapeutic strategies in adult ALL.

【 授权许可】

Unknown