The Effects of Capsaicin on Gastrointestinal Cancers

Molecules

Mihai-Daniel Dumitrache¹  DanielOctavian Costache²  GeorgeDenis Alexandru Popescu³  Ana Caruntu⁴  Constantin Caruntu⁵  IoanaAnca Badarau⁵  Cristian Scheau⁵  Andreea-Elena Scheau⁶  RalucaSimona Costache⁷  Carolina Constantin⁸  Monica Neagu⁸ 

[1] Departament of Pneumology IV, “Marius Nasta” Institute of Pneumophtysiology, 050159 Bucharest, Romania;Department of Dermatology, “Carol Davila” Central Military Emergency Hospital, 010825 Bucharest, Romania;Department of Medical Oncology II, “Prof. Dr. Alexandru Trestioreanu” Institute of Oncology, 022328 Bucharest, Romania;Department of Oral and Maxillofacial Surgery, “Carol Davila” Central Military Emergency Hospital, 010825 Bucharest, Romania;Department of Physiology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania;Department of Radiology and Medical Imaging, Fundeni Clinical Institute, 022328 Bucharest, Romania;Gastroenterology and Internal Medicine Clinic, “Carol Davila” Central Military Emergency Hospital, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania;Immunology Department, Victor Babes National Institute of Pathology, 050096 Bucharest, Romania;

关键词: capsaicin;    digestive cancer;    tumorigenesis;    apoptosis;    molecular signaling;   

DOI  :  10.3390/molecules26010094

来源: DOAJ

【 摘 要 】

Gastrointestinal (GI) cancers are a group of diseases with very high positions in the ranking of cancer incidence and mortality. While they show common features regarding the molecular mechanisms involved in cancer development, organ-specific pathophysiological processes may trigger distinct signaling pathways and intricate interactions with inflammatory cells from the tumoral milieu and mediators involved in tumorigenesis. The treatment of GI cancers is a topic of increasing interest due to the severity of these diseases, their impact on the patients’ survivability and quality of life, and the burden they set on the healthcare system. As the efficiency of existing drugs is hindered by chemoresistance and adverse reactions when administered in high doses, new therapies are sought, and emerging drugs, formulations, and substance synergies are the focus of a growing number of studies. A class of chemicals with great potential through anti-inflammatory, anti-oxidant, and anti-tumoral effects is phytochemicals, and capsaicin in particular is the subject of intensive research looking to validate its position in complementing cancer treatment. Our paper thoroughly reviews the available scientific evidence concerning the effects of capsaicin on major GI cancers and its interactions with the molecular pathways involved in the course of these diseases.

【 授权许可】

Unknown