Hematological parameters predicting severity and mortality in COVID-19 patients of Pakistan: a retrospective comparative analysis

Journal of Community Hospital Internal Medicine Perspectives

Muhammad Sohaib Asghar¹  Maira Hassan²  Gul Muhammad Memon²  Uzma Rasheed²  Mohammed Akram²  Umme Tahniyat²  Noman Ahmed Khan²  Syed Jawad Haider Kazmi²  Aftab Ahmed²  Rumael Jawed²  Syeda Batool Tirmizi³  Muhammad Umer Ahmed⁴ 

[1] Dow University of Health Sciences;Liaquat National Hospital & Medical College;Memon Medical Institute Hospital;Ziauddin University Hospital;

关键词: covid-19;    coronavirus;    hematological parameters;    biochemical markers;    pandemic;    indices;    survivors;    mortality;    intensive care;    infectious disease;   

DOI  :  10.1080/20009666.2020.1816276

来源: DOAJ

【 摘 要 】

Background and Objectives: COVID-19 is a global pandemic. In our study, we aimed to utilize the hematological parameters in predicting the prognosis and mortality in COVID-19 patients. Materials and methods: A retrospective, observational study was conducted to include all the admitted patients (n = 191) having COVID-19 Polymerase chain reaction (PCR) positive, and evaluated those for prognosis and disease outcome by utilizing several biochemical and hematological markers. Results: Amongst the patients admitted in the ward versus in the intensive care unit (ICU), there were significant differences in mean hemoglobin (P = 0.003), total leukocyte count (P = 0.001), absolute neutrophil and lymphocyte counts (P < 0.001), absolute monocyte count (P = 0.019), Neutrophil-to-Lymphocyte ratio (NLR) and Lymphocyte-to-Monocyte ratio (LMR) (P < 0.001), Platelet-to-Lymphocyte ratio (PLR) and Lymphocyte-to C-reactive protein ratio (LCR) (P = 0.002), and C-reactive protein (CRP) levels (P < 0.001). Amongst the deceased patients, there was significant leukocytosis (P = 0.008), neutrophilia and lymphopenia (P < 0.001), increased NLR (P = 0.001), decreased LMR (P < 0.001), increased PLR (p = 0.017), decreased LCR (p = 0.003), and elevated CRP level (P < 0.001). A receiver operating characteristic curve obtained for the above parameters showed NLR (AUC: 0.841, PPV: 83.6%) and PLR (AUC: 0.703, PPV: 81.8%) for ICU patients, while NLR (AUC: 0.860, PPV: 91.1%) and PLR (AUC: 0.677, PPV: 87.5%) for the deceased patients had significant accuracy for predicting the disease severity of COVID-19 in comparison to survivors. Conclusion: The inflammatory markers and hematological indices are a good guide for predicting the severity and disease outcome of coronavirus disease. NLR and PLR are elevated in severe disease while LMR and LCR are inversely correlating with disease severity.

【 授权许可】

Unknown