Triterpenoids from Ainsliaea yunnanensis Franch. and Their Biological Activities

Molecules

Bo Zhang¹  Xiaoya Shang¹  Xuan Zhang²  Hailing Liu²  Changqi Zhao²  Jinjie Li² 

[1] Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China;Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Science, Beijing Normal University, Beijing 100875, China;

关键词: Ainsliaea yunnanensis;    triterpenoids;    NMR;    structures;    activity;   

DOI  :  10.3390/molecules21111481

来源: DOAJ

【 摘 要 】

One new pentacyclic triterpenoid, 3β-carboxylicfilic-4(23)-ene (1), and three known pentacyclic triterpenoids, adian-5-en-3α-ol (2), fernenol (3), and fern-7-en-3β-ol (4) were isolated from the petroleum ether phase of the ethanolic extract of Ainsliaea yunnanensis Franch. Their structures were established by spectroscopic methods including 1-D and 2-D NMR, and MS experiments. Compounds 1, 2, 3, and 4 showed significant selective cytotoxicity against human acute monocytic leukemia cell line (THP-1) with IC50 values of 5.12 μM, 1.78 μM, 1.74 μM, and 1.75 μΜ, respectively. Compound 1 also showed an anti-inflammatory effect through the inhibition of the activity of NF-κB by blocking the nuclear translocation of p65.

【 授权许可】

Unknown