LVAD as a Bridge to Remission from Advanced Heart Failure: Current Data and Opportunities for Improvement

Journal of Clinical Medicine

Antigone G. Koliopoulou¹  Christos P. Kyriakopoulos¹  Michael J. Bonios¹  Konstantinos Sideris¹  Chris J. Kapelios¹  Iosif Taleb¹  Stavros G. Drakos¹  Elizabeth L. Stauder¹  Rana Hamouche² 

[1] Divisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health & School of Medicine, Salt Lake City, UT 84132, USA;Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT 84112, USA;

关键词: heart failure;    mechanical circulatory support;    left ventricular assist device;    reverse remodeling;    myocardial recovery;   

DOI  :  10.3390/jcm11123542

来源: DOAJ

【 摘 要 】

Left ventricular assist devices (LVADs) are an established treatment modality for advanced heart failure (HF). It has been shown that through volume and pressure unloading they can lead to significant functional and structural cardiac improvement, allowing LVAD support withdrawal in a subset of patients. In the first part of this review, we discuss the historical background, current evidence on the incidence and assessment of LVAD-mediated cardiac recovery, and out-comes including quality of life after LVAD support withdrawal. In the second part, we discuss current and future opportunities to promote LVAD-mediated reverse remodeling and improve our pathophysiological understanding of HF and recovery for the benefit of the greater HF population.

【 授权许可】

Unknown