Telomeres and Viruses: Common Themes of Genome Maintenance

Frontiers in Oncology

Zhuo eWang¹  Paul M Lieberman¹  Zhong eDeng¹ 

[1] The Wistar Institute;

关键词: Telomere;    replication;    KSHV;    ebv;    virus;    HHV6;   

DOI  :  10.3389/fonc.2012.00201

来源: DOAJ

【 摘 要 】

Genome maintenance mechanisms actively suppress genetic instability associated with cancer and aging.Some viruses provoke genetic instability by subverting the host’s control of genome maintenance. Viruses have their own specialized strategies for genome maintenance, which can mimic and modify host cell processes.Here, we review some of the common features of genome maintenance utilized by viruses and host chromosomes, with a particular focus on terminal repeat elements. The terminal repeats of cellular chromosomes, better known as telomeres, have well-established roles in cellular chromosome stability. Cellular telomeres are themselves maintained by viral-like mechanisms, including self-propagation by reverse transcription, recombination, and retro-transposition.Viral terminal repeat elements, like cellular telomeres, are essential for viral genome stability and propagation.We review the structure and function of viral repeat elements and discuss how they may share telomere-like structures and genome protection functions.We consider how viral infections modulate telomere regulatory factors for viral repurposing and can alter normal host telomere structure and chromosome stability. Understanding the common strategies of viral and cellular genome maintenance may provide new insights into viral-host interactions and the mechanisms driving genetic instability in cancer.

【 授权许可】

Unknown