High Expression of miR-196b Predicts Poor Prognosis in Patients with Ovarian Cancer

OncoTargets and Therapy

关键词: micrornas;    mir-196b;    ovarian cancer;    cdkn1b;    proliferation;   

DOI  :  

来源: DOAJ

【 摘 要 】

Yang Li,1 Jing Li,2 Zirong Liu,1 Yamin Zhang1 1Department of Hepatobiliary Surgery, Tianjin First Central Hospital, Tianjin 300192, People’s Republic of China; 2Department of Gynaecology, Tianjin First Central Hospital, Tianjin 300192, People’s Republic of ChinaCorrespondence: Yamin Zhang Department of Hepatobiliary SurgeryTianjin First Central Hospital, Tianjin 300192, People’s Republic of ChinaEmail [e-mail]/Aims: To analyze the clinical significance of miR-196b expression in ovarian cancer and predict the function and possible mechanism of miR-196b.Methods: Both Kaplan–Meier (K-M) and Cox proportional hazards regression model were used to analyze the prognostic factors of patients with ovarian cancer. MiR196-b was modulated in ovarian cancer cells, and the cell viability, cell cycle, and cell cycle-related gene expression were analyzed. The target genes of miR-196b were then predicted and checked the relationship between the target genes.Results: MiR-196b was an independent risk factor, while high expression of miR-196b was associated with poor prognosis of ovarian cancer. MiR-196b overexpression increased cancer cell proliferation. Cdkn1b, as one of the targets of miR-196b, was related to cell viability and mitosis.Conclusion: High expression of miR-196b was significantly associated with poor prognosis of the patients with ovarian cancer. MiR-196b could increase the cell proliferation of ovarian cancer by modulating Cdkn1b expression.Keywords: microRNAs, MiR-196b, ovarian cancer, Cdkn1b, proliferation

【 授权许可】

Unknown