Exploring the Imbalance of Periodontitis Immune System From the Cellular to Molecular Level

Frontiers in Genetics

Deshu Zhuang¹  Bo Wang²  Liangjia Bi²  Jiayin Dai²  Longfei He³  Lijuan Liu³  Ti Li³ 

[1] Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada;Department of Stomatology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China;Department of Stomatology, Weifang People’s Hospital, Weifang, China;

关键词: periodontitis;    DEGs;    crosstalk gene;    PPI;    immune system;   

DOI  :  10.3389/fgene.2021.653209

来源: DOAJ

【 摘 要 】

Periodontitis is a common chronic inflammatory disease of periodontal tissue, mostly concentrated in people over 30 years old. Statistics show that compared with foreign countries, the prevalence of periodontitis in China is as high as 40%, and the prevalence of periodontal disease is more than 90%, which must arouse our great attention. Diagnosis and treatment of periodontitis currently rely mainly on clinical criteria, and the exploration of the etiologic criteria is relatively lacking. We, therefore, have explored the pathogenesis of periodontitis from the perspective of immune imbalance. By predicting the fraction of 22 immune cells in periodontitis tissues and comparing them with normal tissues, we found that multiple immune cell infiltration in periodontitis tissues was inhibited and this feature can clearly distinguish periodontitis from normal tissues. Further, protein interaction network (PPI) and transcription regulation network have been constructed based on differentially expressed genes (DEGs) to explore the interaction function modules and regulation pathways. Three functional modules have been revealed and top TFs such as EGR1 and ETS1 have been shown to regulate the expression of periodontitis-related immune genes that play an important role in the formation of the immunosuppressive microenvironment. The classifier was also used to verify the reliability of periodontitis features obtained at the cellular and molecular levels. In conclusion, we have revealed the immune microenvironment and molecular characteristics of periodontitis, which will help to better understand the mechanism of periodontitis and its application in clinical diagnosis and treatment.

【 授权许可】

Unknown