Adaptation of the Golgi Apparatus in Cancer Cell Invasion and Metastasis

Frontiers in Cell and Developmental Biology

Begoña Díaz¹  Isabel Mejia²  Sarah Bui³  Yanzhuang Wang⁴ 

[1] David Geffen School of Medicine and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, United States;Department of Internal Medicine, Division of Medical Hematology and Oncology, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States;Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, United States;Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI, United States;

关键词: Golgi;    cancer;    dissemination;    metastasis;    oncogenic transformation;    proliferation;   

DOI  :  10.3389/fcell.2021.806482

来源: DOAJ

【 摘 要 】

The Golgi apparatus plays a central role in normal cell physiology by promoting cell survival, facilitating proliferation, and enabling cell-cell communication and migration. These roles are partially mediated by well-known Golgi functions, including post-translational modifications, lipid biosynthesis, intracellular trafficking, and protein secretion. In addition, accumulating evidence indicates that the Golgi plays a critical role in sensing and integrating external and internal cues to promote cellular homeostasis. Indeed, the unique structure of the mammalian Golgi can be fine-tuned to adapt different Golgi functions to specific cellular needs. This is particularly relevant in the context of cancer, where unrestrained proliferation and aberrant survival and migration increase the demands in Golgi functions, as well as the need for Golgi-dependent sensing and adaptation to intrinsic and extrinsic stressors. Here, we review and discuss current understanding of how the structure and function of the Golgi apparatus is influenced by oncogenic transformation, and how this adaptation may facilitate cancer cell invasion and metastasis.

【 授权许可】

Unknown