Animal models for filovirus infections

Zoological Research

Gary Wong¹  Xiang-Guo Qiu²  Vinayakumar Siragam² 

[1] Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba R3E 0J9, Canada;Special Pathogens Program, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada;

关键词: Filovirus;    Ebola virus;    Marburg virus;    Marburg virus disease;    Ebola virus disease;    Mouse-adapted ebolavirus;    Guinea-pig-adapted ebolavirus;    Sudan virus;   

DOI  :  10.24272/j.issn.2095-8137.2017.053

来源: DOAJ

【 摘 要 】

The family Filoviridae, which includes the genera Marburgvirus and Ebolavirus, contains some of the most pathogenic viruses in humans and non-human primates (NHPs), causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters, and ferrets have been developed with the goal of screening candidate vaccines and antivirals, before testing in the gold standard NHP models. In this review, we summarize the different animal models used to understand filovirus pathogenesis, and discuss the advantages and disadvantages of each model with respect to filovirus disease research.

【 授权许可】

Unknown