The Influence of Transcranial Magnetoacoustic Stimulation Parameters on the Basal Ganglia-Thalamus Neural Network in Parkinson’s Disease

Frontiers in Neuroscience

Peiguo Wang¹  Yanqiu Zhang²  Mohan Zhang²  Xiqi Jian²  Zichao Ling² 

[1] Department of Radiotherapy, Cancer Institute and Hospital of Tianjin Medical University, Tianjin, China;School of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin, China;

关键词: transcranial magnetoacoustic stimulation;    Parkinson’s disease;    neural network;    Hodgkin-Huxley model;    numerical simulation;   

DOI  :  10.3389/fnins.2021.761720

来源: DOAJ

【 摘 要 】

Objective: Parkinson’s disease (PD) is a degenerative disease of the nervous system that frequently occurs in the aged. Transcranial magnetoacoustic stimulation (TMAS) is a neuronal adjustment method that combines sound fields and magnetic fields. It has the characteristics of high spatial resolution and noninvasive deep brain focusing.Methods: This paper constructed a simulation model of TMAS based on volunteer’s skull computer tomography, phased controlled transducer and permanent magnet. It simulates a transcranial focused sound pressure field with the Westervelt equation and builds a basal ganglia and thalamus neural network model in the PD state based on the Hodgkin-Huxley model.Results: A biased sinusoidal pulsed ultrasonic TMAS induced current with 0.3 T static magnetic field induction and 0.2 W⋅cm–2 sound intensity can effectively modulate PD states with RI ≥ 0.633. The magnitude of magnetic induction strength was changed to 0.2 and 0.4 T. The induced current was the same when the sound intensity was 0.4 and 0.1 W⋅cm–2. And the sound pressure level is in the range of −1 dB (the induced current difference is less than or equal to 0.019 μA⋅cm–2). TMAS with a duty cycle of approximately 50% can effectively modulates the error firings in the PD neural network with a relay reliability not less than 0.633.Conclusion: TMAS can modulates the state of PD.

【 授权许可】

Unknown