Switching modes in corticogenesis: mechanisms of neuronal subtype transitions and integration in the cerebral cortex

Frontiers in Neuroscience

Carina eHanashima¹  Kenichi eToma¹ 

[1] RIKEN;

关键词: Neocortex;    Transcription Factors;    Migration;    network;    mouse models;    cell fate specification;   

DOI  :  10.3389/fnins.2015.00274

来源: DOAJ

【 摘 要 】

Information processing in the cerebral cortex requires the activation of diverse neurons across layers and columns, which are established through the coordinated production of distinct neuronal subtypes and their placement along the three-dimensional axis. Over recent years, our knowledge of the regulatory mechanisms of the specification and integration of neuronal subtypes in the cerebral cortex has progressed rapidly. In this review, we address how the unique cytoarchitecture of the neocortex is established from a limited number of progenitors featuring neuronal identity transitions during development. We further illuminate the molecular mechanisms of the subtype-specific integration of these neurons into the cerebral cortex along the radial and tangential axis, and we discuss these key features to exemplify how neocortical circuit formation accomplishes economical connectivity while maintaining plasticity and evolvability to adapt to environmental changes.

【 授权许可】

Unknown