Recent Advances in Association of Estrogen and Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer

Jun LIANG¹  Zhijie WANG¹  Xiaosheng DING¹  Chuanhao TANG¹ 

[1] Department of Oncology, Peking University International Hospital, Beijing 102206, China;

关键词: Lung neoplasms;    Estrogen;    Estrogen receptors;    Antiestrogens;    Epidermal growth factor receptor tyrosine kinase inhibitor;   

DOI  :  10.3779/j.issn.1009-3419.2017.07.09

来源: DOAJ

【 摘 要 】

Lung cancer, of which approximately 85% are non-small cell lung cancer (NSCLC), is one of the most prevalent cancers and the most leading cause of cancer mortality. Despite recent improvements in its treatment, the prognosis remains dismal. Previous studies have clearly proved that estrogen and estrogen receptors (ER) are involve in the pathogenesis and development of lung cancer. More and more evidences showed antiestrogen therapy may reverse the drug-resistance of platinum based chemotherapy in NSCLC patients and can enhance curative effect of epidermal growth factor receptor tyrosine kinase inhibitor. We will review recent progress in the function of estrogen in NSCLC and the treatment based on the ER signaling pathways for NSCLC in this article.

【 授权许可】

Unknown