Spatial and chronic differences in neural activity in medicated and unmedicated schizophrenia patients

NeuroImage: Clinical

Rongjun Yu¹  Zachary Adam Yaple²  Serenella Tolomeo³ 

[1] Department of Management, Hong Kong Baptist University, Hong Kong, China;Department of Psychology, York University, Toronto, Canada;Social and Cognitive Computing Department, Institute of High Performance Computing, Agency for Science, Technology and Research, Singapore, Singapore;

关键词: Schizophrenia;    fMRI meta-analysis;    Medication;   

DOI  :  

来源: DOAJ

【 摘 要 】

A major caveat with investigations on schizophrenic patients is the difficulty to control for medication usage across samples as disease-related neural differences may be confounded by medication usage. Following a thorough literature search (632 records identified), we included 37 studies with a total of 740 medicated schizophrenia patients and 367 unmedicated schizophrenia patients. Here, we perform several meta-analyses to assess the neurofunctional differences between medicated and unmedicated schizophrenic patients across fMRI studies to determine systematic regions associated with medication usage. Several clusters identified by the meta-analysis on the medicated group include three right lateralized frontal clusters and a left lateralized parietal cluster, whereas the unmedicated group yielded concordant activity among right lateralized frontal-parietal regions. We further explored the prevalence of activity within these regions across illness duration and task type. These findings suggest a neural compensatory mechanism across these regions both spatially and chronically, offering new insight into the spatial and temporal dynamic neural differences among medicated and unmedicated schizophrenia patients.

【 授权许可】

Unknown