Nasal Methicillin-Resistant Staphylococcus aureus Colonization in Patients with Type 1 Diabetes in Taiwan

Microorganisms

Chi-Chun Lai¹  Fu-Sung Lo¹  Yhu-Chering Huang¹  Eugene Yu-Chuan Kang¹  Kun-Jen Chen¹  Yih-Shiou Hwang¹  Wei-Chi Wu¹  Laura Liu¹  Wei-Che Lo²  Chun-Ya Kang³ 

[1] College of Medicine, Chang Gung University, Taoyuan 333, Taiwan;Department of Ophthalmology, Keelung Chang Gung Memorial Hospital, Keelung 204, Taiwan;School of Medicine, Medical University of Lublin, 20529 Lublin, Poland;

关键词: Staphylococcus aureus;    methicillin-resistant;    nasal colonization;    type 1 diabetes;    molecular;    epidemiology;   

DOI  :  10.3390/microorganisms9061296

来源: DOAJ

【 摘 要 】

Nasal methicillin-resistant Staphylococcus aureus (MRSA) colonies are an essential reservoir of infection, especially for patients with diabetes. However, data on MRSA colonization in patients with type 1 diabetes are limited. We investigated the epidemiology of MRSA colonization in patients with type 1 diabetes. This prospective cross-sectional study was conducted in a medical center (Chang Gung Memorial Hospital) in Taiwan from 1 July to 31 December 2020. Nasal sampling and MRSA detection were performed. The molecular characteristics of MRSA isolates were tested, and factors associated with MRSA colonization were analyzed. We included 245 patients with type 1 diabetes; nasal MRSA colonization was identified in 13 (5.3%) patients. All isolates belonged to community-associated MRSA genetic strains; the most frequent strain was clonal complex 45 (53.8%), followed by ST59 (30.8%) (a local community strain). MRSA colonization was positively associated with age ≤ 10 years, body mass index < 18 kg/m², and diabetes duration < 10 years; moreover, it was negatively associated with serum low-density lipoprotein cholesterol ≥ 100 mg/dL. No independent factor was reported. The nasal MRSA colonization rate in type 1 diabetes is approximately 5% in Taiwan. Most of these colonizing strains are community strains, namely clonal complex 45 and ST59.

【 授权许可】

Unknown