Resveratrol Favors Adhesion and Biofilm Formation of Lacticaseibacillus paracasei subsp. paracasei Strain ATCC334

International Journal of Molecular Sciences

Ali Assifaoui¹  Jana Al Azzaz¹  Alissar Al Tarraf¹  Julie Laurent¹  Pierre Lapaquette¹  David Da Silva Barreira¹  Aurélie Rieu¹  Arnaud Heumann¹  Jean Guzzo¹ 

[1] Université de Bourgogne Franche-Comté (UBFC), AgroSup Dijon, F-21000 Dijon, France;

关键词: Probiotic;    Lacticaseibacillus;    Lactobacillus;    Resveratrol;    polyphenols;    biofilm;   

DOI  :  10.3390/ijms21155423

来源: DOAJ

【 摘 要 】

Bacterial strains of the Lactobacillaceae family are widely used as probiotics for their multifaceted potential beneficial properties. However, no official recommendations for their clinical use exist since, in many cases, oral administrations of these bacteria displayed limited beneficial effects in human. Additional research is thus needed to improve the efficiency of existing strains with strong potential. In this context, we assess in vitro the effects of nine polyphenols to stimulate biofilm formation by lactobacilli, a feature enhancing their functionalities. Among these polyphenols, we identify trans-Resveratrol (referred to hereafter as Resveratrol) as a potent inducer of biofilm formation by Lacticaseibacillus paracasei (formerly designated as Lactobacillus paracasei) ATCC334 strain. This effect is strain-dependent and relies on the enhancement of L. paracasei adhesion to abiotic and biotic surfaces, including intestinal epithelial cells. Mechanistically, Resveratrol modify physico-chemical properties of the bacterial surface and thereby enhances L. paracasei aggregation, subsequently facilitating adhesion and biofilm development. Together, our in vitro data demonstrate that Resveratrol might be used to modulate the behavior of Lactobacilli with probiotic properties. Combination of probiotics and polyphenols could be considered to enhance the probiotic functionalities in further in vivo studies.

【 授权许可】

Unknown