期刊论文详细信息
Al-Khawarizmi Engineering Journal
Experimental Study of Drug Delivery system for Prednisolone Loaded and Released by Mesoporous Silica MCM-41
Talib M. Albayati1  Abd Alkadir A. Jassam1 
[1] Department of Chemical Engineering/ University of Technology/ Baghdad/ Iraq;
关键词: Drug delivery, Kinetics model, MCM-41, Prednisolone.;   
DOI  :  
来源: DOAJ
【 摘 要 】

In the present study, nanoporous material type MCM-41 was prepared by the sol-gel technique and was used as a carrier for prednisolone (PRD) drug delivery. The structural properties of mesoporous were fully characterized by X-ray diffraction (XRD), N2 adsorption /desorption and Fourier-transform infrared (FTIR). The mass transfer in term of adsorption process (loading) and desorption process (releasing) properties were investigated. The maximum drug loading efficiency was equal to 38% and 47.5% at different concentrations. The PRD released was prudently studied in water media of pH 6.8 simulated body fluid (SBF) in according to "United State Pharmacopeia (USP38)". The results proved that the release of prednisolone from MCM-41 was (69.4%) after 24 hr. The data of the released PRD was found to be submitted to a Korsmeyer–Peppas model.

【 授权许可】

Unknown   

  文献评价指标  
  下载次数:0次 浏览次数:0次