Sex and Response to Cardioprotective Conditioning Maneuvers

Frontiers in Physiology

Claudia Penna¹  Susanna Antoniotti²  Federica Geddo²  Giulia Querio²  Maria Pia Gallo² 

[1] Department of Clinical and Biological Sciences, University of Turin, Turin, Italy;Department of Life Sciences and Systems Biology, University of Turin, Turin, Italy;

关键词: cardioprotection;    ischemic heart disease;    estrogen;    sex;    conditioning;    gender;   

DOI  :  10.3389/fphys.2021.667961

来源: DOAJ

【 摘 要 】

Ischemic heart disease (IHD) is a multifactorial pathological condition strictly related to genetic, dietary, and lifestyle factors. Its morbidity and mortality rate represent one of the most important pathological issues that today involve younger people in a stronger way than in the past. IHD clinical outcomes are difficult to treat and have a high economic impact on health care. So prevention of this pathological condition through cardioprotective maneuvers represents the first line of intervention, as already underlined by several animal and human studies. Even if the time of intervention is important to prevent severe outcomes, many studies highlight that sex-dependent responses are crucial for the result of cardioprotective procedures. In this scenario sexual hormones have revealed an important role in cardioprotective approach, as women seem to be more protected toward cardiac insults when compared to male counterparts. The aim of this mini review is to show the molecular pathways involved in cardioprotective protocols and to elucidate how sexual hormones can contribute in ameliorating or worsening the physiological responses to IHD.

【 授权许可】

Unknown