Pattern of Prostate Cancer Recurrence Assessed by 68Ga-PSMA-11 PET/CT in Men Treated with Primary Local Therapy

Journal of Clinical Medicine

Gbenga O. Popoola¹  Akintunde T. Orunmuyi²  Mike M. Sathekge³  Kgomotso M. G. Mokoala³  Thabo Lengana³  Mankgopo M. Kgatle³  Ismaheel O. Lawal³ 

[1] Department of Epidemiology and Community Health, University of Ilorin, Ilorin 240102, Nigeria;Department of Nuclear Medicine, University of Ibadan, Ibadan 200284, Nigeria;Department of Nuclear Medicine, University of Pretoria, Pretoria 0001, South Africa;

关键词: prostate cancer;    radical prostatectomy;    radiotherapy;    biochemical recurrence;    PSMA;    PET/CT;   

DOI  :  10.3390/jcm10173883

来源: DOAJ

【 摘 要 】

Imaging plays a vital role in detecting the recurrence of prostate cancer (PCa) to guide the choice of salvage therapy. Gallium-68 prostate-specific membrane antigen positron-emission tomography/computed tomography (⁶⁸Ga-PSMA-11 PET/CT) is useful for detecting PCa recurrence. We assessed the pattern of PCa recurrence stratified by serum prostate-specific antigen level and type of primary local treatment in men with biochemical recurrence (BCR) after primary local therapy with radical prostatectomy or external beam radiotherapy (EBRT) using ⁶⁸Ga-PSMA-11 PET/CT. We reviewed patients imaged with ⁶⁸Ga-PSMA-11 PET/CT for the localization of the site of PCa recurrence. We determined the site and number of lesions due to PCa recurrence at different PSA levels. A total of 247 men (mean age of 65.72 ± 7.51 years and median PSA of 2.70 ng/mL (IQR = 0.78–5.80)) were included. ⁶⁸Ga-PSMA-11 PET/CT detected the site of recurrence in 81.4% of patients with a median number of lesions per patient of 1 (range = 1–5). ⁶⁸Ga-PSMA-11 PET/CT positivity was 43.6%, 75.7%, 83.3%, 90.0%, and 95.8% at PSA levels of <0.5, 0.5–1.0., 1.1–2.0, 2.1–5.0, and 5.0–10.0, respectively. The most common site of recurrence was in the prostate gland/bed at all PSA levels. Pelvic, extra-pelvic, and combined pelvic and extra-pelvic sites of recurrence were seen in 118, 50, and 33 patients, respectively. The risk of extra-pelvic recurrence increases with rising PSA levels. ⁶⁸Ga-PSMA-11 PET/CT has a high lesion detection rate for biochemical recurrence of PCa in patients previously treated with primary local therapy.

【 授权许可】

Unknown