Evaluation of Antioxidant Supplementation on Redox Unbalance in Hyperthyroid Cats Treated with Methimazole: A Blinded Randomized Controlled Trial

Antioxidants

Graziella Raviri¹  Paola Badino²  Giorgia Meineri²  Flavia Girolami²  Alessia Candellone²  Paola Gianella²  Vittorio Saettone² 

[1] Ambulatorio Veterinario Antica Reggia Della Dott.Ssa G. Raviri. Piazza V. Veneto, 3, 10078 Venaria (TO), Italy;Department of Veterinary Sciences, University of Turin. L.go Braccini, 2, 10095 Grugliasco (TO), Italy;

关键词: antioxidants;    quercetin;    curcumin;    resveratrol;    vitamin e;    redox unbalance;    feline hyperthyroidism;    methimazole;   

DOI  :  10.3390/antiox9010015

来源: DOAJ

【 摘 要 】

Methimazole (MMI) is often the selected medical treatment for feline hyperthyroidism. However, the onset of MMI-related side effects (MMI-SE) is likely caused by oxidative stress. This study evaluated the dietary supplementation of selected antioxidants in hyperthyroid cats receiving MMI, to reduce MMI-SE. Thirty hyperthyroid client-owned cats were randomly allocated in group M (MMI + placebo) or group M+A (MMI + antioxidants). At different time-points from the enrolment (ET) to the end of the trial (FT), the following information was recorded: clinical findings, complete blood count, serum biochemical parameters, urinalysis, total plasma thyroxine concentrations, determinable reactive oxygen metabolites (dROMs), OXY-adsorbent test values, and oxidative stress index (OSi) values, and MMI-SE. dROMs and OSi values significantly increased from ET to FT in group M and were significantly higher in group M than in group M+A at FT. Likewise, OXY-absorbent test values were significantly higher in group M+A than in group M at FT. Moreover, the occurrence rate of MMI-SE in group M+A was lower than in group M. In conclusion, our results show that the dietary supplementation of antioxidants in hyperthyroid cats receiving MMI exerts a protective effect against oxidative stress, likely contributing to the reduction of MMI-SE.

【 授权许可】

Unknown