Re-infection with a different SARS-CoV-2 clade and prolonged viral shedding in a hematopoietic stem cell transplantation patient

International Journal of Infectious Diseases

Intikhab Alam¹  Ashraf Dada²  Mohammed F. Saeedi²  Ahmed M. Tolah²  Takashi Gojobori³  Norah A. Othman⁴  Thamir A. Alandijany⁴  Tagreed L. Alsubhi⁴  Aleksandar Radovanovic⁵  Naif I. AlJohani⁶  Ahmed Aljohaney⁶  Husam A. Bahaudden⁶  Abeer N. Alshukairi⁶  Muhammad Yasir⁷  Amani H. Yamani⁸  Sherif A. El-Kafrawy⁸  Esam I Azhar⁸  Jaffar A. Al-Tawfiq⁸  Ahmed M. Hassan⁸  Alimuddin Zumla⁸ 

[1] Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia;Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia;Adult Hematology and Bone Marrow Transplant Section, Oncology Department, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia;Computational Bioscience Research Centre, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia;Department of Medicine, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia;Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia;Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia;Special Infectious Agents Unit-BSL3, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia;

关键词: SARS-CoV-2;    Re-infection;    Prolonged viral shedding;    Immunocompromised;    Hematological stem cell transplant;    COVID-19;   

DOI  :  

来源: DOAJ

【 摘 要 】

Immunocompromised patients who have a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection pose many clinical and public health challenges. We describe the case of a hematopoietic stem cell transplantation patient with lymphoma who had a protracted illness requiring three consecutive hospital admissions. Whole genome sequencing confirmed two different SARS-CoV-2 clades. Clinical management issues and the unanswered questions arising from this case are discussed.

【 授权许可】

Unknown