Case Report: Tissue Origin Identification for Cancer of Unknown Primary: Gene Expression Profiling Approach

Frontiers in Oncology

Qian Gong¹  Sa Yang²  Xingxiang Pu³  Qianzhi Wang³  Lin Wu³  Bolin Chen³  Yan Xu³ 

[1] Department of Pharmacy, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China;Department of Pharmacy, Xiangxiang People’s Hospital, Xiangxiang, China;Department of Thoracic Medical Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China;

关键词: cancer of unknown primary;    gene expression profiling;    tissue of origin;    real-time PCR;    immunohistochemistry;   

DOI  :  10.3389/fonc.2021.702887

来源: DOAJ

【 摘 要 】

The treatment of cancer of unknown primary (CUP) is a huge challenge for clinicians. Gene expression profiling can help identify the tissue origin of tumors by detecting the expression levels of specific genes in tumor tissues. Herein, we report four CUP cases. All of them have been successfully identified with the corresponding primary tumor sites through gene expression profiling analysis. Then all patients received accurate treatment, providing reference to guide therapeutic decisions to treat CUP tumors in the future.

【 授权许可】

Unknown