Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches—An Overview

Pharmaceutics

Isaac Fuentes-Boquete¹  Silvia Díaz-Prado¹  Ana Rey-Rico¹  Natalia Carballo-Pedrares¹ 

[1] Cell Therapy and Regenerative Medicine Unit, Centro de Investigacións Científicas Avanzadas (CICA), Universidade da Coruña, 15071 A Coruña, Spain;

关键词: musculoskeletal tissue;    cardiovascular tissue;    wound healing;    nervous tissue;    gene therapy;    controlled delivery;   

DOI  :  10.3390/pharmaceutics12080752

来源: DOAJ

【 摘 要 】

Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular, or neural tissues disorders as well as wound healing. By a minimally invasive administration, these systems can provide a spatially and temporarily defined supply of specific gene sequences into the target tissue cells that are overexpressing or silencing the original gene, which can promote natural repairing mechanisms to achieve the desired effect. In the present work, we provide an overview of the most avant-garde approaches using various hydrogels systems for controlled delivery of therapeutic nucleic acid molecules in different regenerative medicine approaches.

【 授权许可】

Unknown