NT-proBNP <95 ng/l can exclude pulmonary hypertension on echocardiography at diagnostic workup in patients with interstitial lung disease

European Clinical Respiratory Journal

Søren Mellemkjær¹  Charlotte Andersen²  Ole Hilberg³  Elisabeth Bendstrup³ 

[1] Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark;Department of Clinical Pharmacology, Aarhus University Hospital, Aarhus, Denmark;Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark;

关键词: lung fibrosis;    biomarker;    brain natriuretic peptides;    diagnosis;    cor pulmonale;    idiopathic pulmonary fibrosis;    IPF;   

DOI  :  10.3402/ecrj.v3.32027

来源: DOAJ

【 摘 要 】

Background: Pulmonary hypertension (PH) is a serious complication to interstitial lung disease (ILD) and has a poor prognosis. PH is often diagnosed by screening with echocardiography followed by right heart catheterisation. A previous study has shown that a value of NT-pro-brain natriuretic peptide (NT-proBNP) <95 ng/l could be used to rule out PH in patients with ILD. Aim: To evaluate this rule-out test for PH in a new cohort of incident patients with ILD. Methods: An established database with data from 148 consecutive patients referred from January 2012 to October 2014 was used to identify patients and obtain data from echocardiography, NT-proBNP, diagnosis and lung function. Signs of PH on echocardiography were defined as a tricuspid pressure gradient (TR) ≥40 mmHg, decreased right ventricular systolic function or dilatation. Sensitivity, specificity, negative predictive value (NPV) and positive predictive value (PPV) of NT-proBNP >95 ng/l for signs of PH on echocardiography were calculated. The study was approved by the Danish Health Authority. Results: In 118 patients, data from both echocardiography and measurements of NT-proBNP were available. Eleven of these were screened positive for PH on echocardiography. Sensitivity, specificity, NPV and PPV of NT-proBNP <95 ng/l for PH were 100, 44, 16 and 100%, respectively. Furthermore, no patients with left heart failure as the cause of dyspnoea were missed using this cut-off value. Conclusion: NT-proBNP <95 ng/l precludes a positive echocardiographic screen for PH in ILD patients at referral for diagnostic workup.

【 授权许可】

Unknown