A novel optical biosensor for the early diagnosis of sepsis and severe Covid-19: the PROUD study

BMC Infectious Diseases

Gennaios Christopoulos¹  Konstantinos Leventogiannis²  Miltiades Kyprianou²  Sarantia Doulou²  Emmanouil Karofylakis²  Evangelos J. Giamarellos-Bourboulis²  Athanassios Karageorgos²  Nikolaos Antonakos²  Panagiotis Koufargyris²  Maria Tsilika²  Konstantina Katrini²  Kimon Stamatelopoulos³  George Kassianidis⁴  Matthew Rodencal⁵  Robert Newberry⁵ 

[1] 2nd Department of Critical Care Medicine, National and Kapodistrian University of Athens, Medical School;4th Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School;Department of Therapeutics, National and Kapodistrian University of Athens;Intensive Care Unit, Korgialeneion Benakeion Athens General Hospital;Sanmina Corporation;

关键词: Sepsis;    Optical biosensor;    Diagnosis;    Severity;    COVID-19;    SARS-CoV-2;   

DOI  :  10.1186/s12879-020-05607-1

来源: DOAJ

【 摘 要 】

Abstract Background The accuracy of a new optical biosensor (OB) point-of-care device for the detection of severe infections is studied. Methods The OB emits different wavelengths and outputs information associated with heart rate, pulse oximetry, levels of nitric oxide and kidney function. At the first phase, recordings were done every two hours for three consecutive days after hospital admission in 142 patients at high-risk for sepsis by placing the OB on the forefinger. At the second phase, single recordings were done in 54 patients with symptoms of viral infection; 38 were diagnosed with COVID-19. Results At the first phase, the cutoff value of positive likelihood of 18 provided 100% specificity and 100% positive predictive value for the diagnosis of sepsis. These were 87.5 and 91.7% respectively at the second phase. OB diagnosed severe COVID-19 with 83.3% sensitivity and 87.5% negative predictive value. Conclusions The studied OB seems valuable for the discrimination of infection severity.

【 授权许可】

Unknown