In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes

Frontiers in Cell and Developmental Biology

César Cárdenas²  Alenka Lovy³  Ulises Ahumada-Castro⁴  Eduardo Silva-Pavez⁴  Andrea Puebla-Huerta⁴  Galdo Bustos⁴ 

[1] Buck Institute for Research on Aging, Novato, CA, United States;Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, United States;Department of Neuroscience, Center for Neuroscience Research, Tufts University School of Medicine, Boston, MA, United States;Geroscience Center for Brain Health and Metabolism, Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago, Chile;

关键词: IP3Rs;    calcium;    endoplasmic reticulum;    mitochondria;    lysosome;    metabolism;   

DOI  :  10.3389/fcell.2021.629522

来源: DOAJ

【 摘 要 】

In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)-mediated calcium (Ca2+) release plays a central role. Recent evidence suggests that IP3R isoforms participate in synthesis and degradation pathways. This minireview will summarize the current findings in this area, emphasizing the critical role of Ca2+ communication on organelle function as well as catabolism and anabolism, particularly in cancer.

【 授权许可】

Unknown