Association of CDKN2BAS Polymorphism rs4977574with Coronary Heart Disease: A Case-Control Studyand a Meta-Analysis

International Journal of Molecular Sciences

Yi Huang¹  Xiang Gao¹  Jie Sun¹  Qingxiao Hong²  Danjie Jiang²  Limin Xu²  Shiwei Duan²  Dongjun Dai²  Huadan Ye²  Xuting Xu² 

[1] Department of Neurosurgery, Ningbo First Hospital, Ningbo 315010, China;Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo 315211, China;

关键词: coronary heart disease;    single nucleotide polymorphism (SNP);    CDKN2BAS;    meta–analysis;   

DOI  :  10.3390/ijms151017478

来源: DOAJ

【 摘 要 】

The goal of our study was to explore the significant association between a non-protein coding single nucleotide polymorphism (SNP) rs4977574 of CDKN2BAS gene and coronary heart disease (CHD). A total of 590 CHD cases and 482 non-CHD controls were involvedin the present association study. A strong association of rs4977574 with CHD was observedin females (genotype: p = 0.002; allele: p = 0.002, odd ratio (OR) = 1.57, 95% confidential interval (CI) = 1.18–2.08). Moreover, rs4977574 was more likely to be a risk variant of CHD under the recessive model in females (χ2 = 10.29, p = 0.003, OR = 2.14, 95% CI = 1.31–2.77).A breakdown analysis by age had shown that there was an 87% increased risk of CHDfor females younger than 65 years (genotype: χ2 = 14.64, degrees of freedom (df) = 2,p = 0.0002; allele: χ2 = 11.31, df = 1, p = 0.0008, OR = 1.87, 95% CI = 1.30–2.70). Similar observation was also found in males younger than 65 years (genotype: χ2 = 8.63, df = 2, p = 0.04; allele: χ2 = 7.55, df = 1, p = 0.006, OR = 1.45, 95% CI = 1.11–1.90). p values wereadjusted by age, sex, smoking, high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). Meta-analysis of 23 studies among 36,452 cases and39,781 controls showed a strong association between rs4977574 and the risk of CHD(p < 0.0001, OR = 1.27, 95% CI = 1.22–1.31).

【 授权许可】

Unknown