Prevalence of Mental Disorders and Impact on Quality of Life in Patients With Pulmonary Arterial Hypertension

Frontiers in Psychiatry

Henning Gall¹  Manuel J. Richter¹  Hossein A. Ghofrani²  Kai G. Kahl³  Nicole Lepsy³  Ivo Heitland³  Madelaine-Rachel Dering³  Tanja Meltendorf³  Karen M. Olsson⁴  Jan C. Kamp⁴  Da-Hee Park⁴  Jan Fuge⁴  Marius M. Hoeper⁴  Pisana Ferrari⁵  Ralf Schmiedel⁶  Hans-Dieter Kulla⁷ 

[1] Department of Internal Medicine, German Center for Lung Research (DZL), Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center, Giessen, Germany;Department of Pneumology, German Center for Lung Research (DZL), Kerckhoff Heart, Rheuma and Thoracic Center, Universities of Giessen and Marburg Lung Center, Bad Nauheim, Germany;Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School, Hannover, Germany;Department of Respiratory Medicine, German Center for Lung Research Biomedical Research in Endstage and Obstructive Lung Disease Hannover (DZL/BREATH), Hannover Medical School, Hannover, Germany;Italian Pulmonary Hypertension (PH) Association Associazione Ipertensione Polmonare Italiana (AIPI), Bologna, Italy;Pulmonale Hypertonie Selbsthilfe, Bottrop, Germany;Pulmonale Hypertonie eV, Rheinstetten, Germany;

关键词: pulmonary arterial hypertension;    anxiety disorder;    adjustment disorder;    psychocardiology;    quality of life;    depression disorder;   

DOI  :  10.3389/fpsyt.2021.667602

来源: DOAJ

【 摘 要 】

Objective: Mental health may affect the quality of life (QoL) in patients with pulmonary arterial hypertension (PAH). However, mental disorders have not been systematically assessed in these patients. We examined the prevalence of mental disorders using structured interviews and determined their impact on QoL in patients with PAH.Methods: This study included 217 patients with PAH from two German referral centers. Psychiatric disorders were assessed using the structured clinical interview for DSM-V. QoL was assessed using the WHO Quality of Life questionnaire (short form). The diagnostic value of the Hospital Anxiety and Depression Scale was evaluated by receiver operating characteristic curve analysis.Results: More than one third of the patients had psychological disorders with current or past adjustment disorder (38.2%), current major depressive disorder (23.0%), and panic disorder (15.2%) being the most prevalent mental illnesses. About half of the patients with a history of adjustment disorder developed at least one other mental illness. The presence of mental disorders had a profound impact on QoL. The Hospital Anxiety and Depression Scale ruled out panic disorder and depression disorder with negative predictive values of almost 90%.Conclusion: Mental disorders, in particular adjustment disorder, major depression, and panic disorder, are common in patients with PAH and contribute to impaired QoL in these patients. The Hospital Anxiety and Depression Scale may be used as a screening tool for the most common mental health disorders. Future studies need to address interventional strategies targeting mental disorders in patients with PAH.

【 授权许可】

Unknown