Src family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation

The Journal of Headache and Pain

Minyan Wang¹  Lingdi Nie¹  Dongqing Ma¹  John P. Quinn² 

[1] Department of Biological Sciences, Centre for Neuroscience, Xi’an Jiaotong-Liverpool University (XJTLU);Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology;

关键词: Migraine;    cortical spreading depression;    P2X7 receptor;    Src family kinases;    glutamatergic pathway;    neuroinflammation;   

DOI  :  10.1186/s10194-021-01359-8

来源: DOAJ

【 摘 要 】

Highlights • SFKs activity-mediated P2X7 receptor signaling facilitates CSD propagation via glutamatergic pathway and also promotes neuroinflammation. • P2X7 receptor/SFKs signaling can be targeted for migraine prophylaxis and therapy.

【 授权许可】

Unknown