Characterising Functional Venom Profiles of Anthozoans and Medusozoans within Their Ecological Context

Marine Drugs

Eivind A. B. Undheim¹  Raymond S. Norton²  David A. Hurwood³  Peter J. Prentis³  Lauren M. Ashwood³ 

[1] Centre for Biodiversity Dynamics, Department of Biology, Norwegian University of Science and Technology, 7491 Trondheim, Norway;Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia;School of Biology and Environmental Science, Science and Engineering Faculty, Queensland University of Technology, Brisbane, QLD 4000, Australia;

关键词: Cnidaria;    Anthozoa;    Medusozoa;    venom;    toxins;    transcriptomics;   

DOI  :  10.3390/md18040202

来源: DOAJ

【 摘 要 】

This review examines the current state of knowledge regarding toxins from anthozoans (sea anemones, coral, zoanthids, corallimorphs, sea pens and tube anemones). We provide an overview of venom from phylum Cnidaria and review the diversity of venom composition between the two major clades (Medusozoa and Anthozoa). We highlight that the functional and ecological context of venom has implications for the temporal and spatial expression of protein and peptide toxins within class Anthozoa. Understanding the nuances in the regulation of venom arsenals has been made possible by recent advances in analytical technologies that allow characterisation of the spatial distributions of toxins. Furthermore, anthozoans are unique in that ecological roles can be assigned using tissue expression data, thereby circumventing some of the challenges related to pharmacological screening.

【 授权许可】

Unknown