LncRNA MIR31HG functions as a ceRNA to regulate c-Met function by sponging miR-34a in esophageal squamous cell carcinoma

Biomedicine & Pharmacotherapy

Fucheng He¹  Junhu Wan²  Huiqing Yin³  Yunhui Qu³  Jinlin Jia³  Lijun Yang³  Jie Chu³ 

[1] Department of Medical Laboratory, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan Province, China;Corresponding authors at: The First Affiliated Hospital, Zhengzhou University, Jianshe Dong Road 1, Zhengzhou, Henan Province, China.;Department of Medical Laboratory, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan Province, China;

关键词: Esophageal squamous cell carcinoma;    Long non-coding RNA;    MIR31HG;    MiR-34a;    c-Met;   

DOI  :  

来源: DOAJ

【 摘 要 】

Accumulating evidence has demonstrated that long non-coding RNAs (lncRNAs) function as essential regulators in the development and progression of multiple tumors. However, the molecular mechanisms of MIR31HG in regulating ESCC progression remain unknown. Here, we confirmed that MIR31HG facilitated ESCC cells proliferation in vivo. Besides, MIR31HG knockdown increases the percentage of cells at the G1 phase, along with reduced arrest in S phase and MIR31HG overexpression exhibits the opposite effects. Overexpressed MIR31HG decreases the percentage of apoptotic ESCC cells. Interestingly, MIR31HG can function as a competing endogenous RNA by sponging miR-34a. The rescue experiments demonstrated that MIR31HG function is partially reversed by inhibiting miR-34a. In addition, we found c-Met is a target gene of miR-34a and is indirectly regulated by MIR31HG. Taken together, our findings revealed that MIR31HG promotes ESCC progression by regulating miR-34a/ c-Met axis and may provide a new prospective for exploration and understanding of the biological effects of esophageal squamous cell carcinoma.

【 授权许可】

Unknown