Selectively down-regulated PD-L1 by albumin-phenformin nanoparticles mediated mitochondrial dysfunction to stimulate tumor-specific immunological response for enhanced mild-temperature photothermal efficacy

Journal of Nanobiotechnology

Ruogu Qi¹  Yuanyuan Guo¹  Ruirong Ye²  Ning Jiang²  Jianliang Shen³  Jiashe Chen³  Zaigang Zhou³  Chunjuan Zheng³ 

[1] Department of Biochemistry and Molecular Biology, School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine;Faculty of Life Science and Technology, Kunming University of Science and Technology;State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University;

关键词: Mitochondrial inhibition;    Mild-temperature photothermal therapy;    Programmed cell death-ligand 1;    Biomineralization;    Tumor metastasis;   

DOI  :  10.1186/s12951-021-01124-8

来源: DOAJ

【 摘 要 】

Highlights Over-expression of PD-L1 after mild-photothermal therapy significantly limited its efficacy. Phenformin could effectively downregulate PD-L1 expression and inhibit tumor metastasis through AMPK activation. Hydrogen peroxide responsive manganese dioxide mineralized albumin nanocomplex co-loading with phenformin and ICG named ICG@PM@NP was constructed by modified two-step biomineralization method. ICG@PM@NP could enhance T cell infiltration and antitumor metastasis in vivo. ICG@PM@NP mediated mild-photothermal therapy could make up the defects of conventional mild-photothermal therapy in lacking the anti-metastasis ability and inducing enhanced PD-L1 expression.

【 授权许可】

Unknown