Leukocyte Lipid Peroxidation, Superoxide Dismutase and Catalase Activities of Type 2 Diabetic Patients with Retinopathy

Acta Medica

Naciye Kurtul¹  Hülya Aksoy²  Ebubekir Bakan²  Orhan Baykal³ 

[1] KSU, Kahramanmaras, Faculty of Science, Department of Chemistry, Turkey;Medical School, Atatürk University, Department of Biochemistry, Erzurum, Turkey;Medical School, Atatürk University, Department of Ophtalmology, Erzurum, Turkey;

关键词: Diabetes;    Diabetic retinopathy;    Lipid peroxidation;    Superoxide dismutase;    Catalase;   

DOI  :  10.14712/18059694.2018.26

来源: DOAJ

【 摘 要 】

Increased oxidative stress might play an important role in the initiation and progression of diabetic complications. The present study has been undertaken to investigate whether there is any relationship between retinopathy degree and leukocyte superoxide dismutase (SOD) and catalase (CAT) activities and lipid peroxidation (LPO) in diabetic individuals with type 2 diabetic retinopathy. Patients were groupped with respect to the degree of retinopathy. Leukocyte malondialdehyde (MDA) levels, and SOD and CAT activities were measured in patients with type 2 diabetes mellitus (n=41) and nondiabetic healthy controls (n=23). Leukocyte LPO of the type 2 diabetic patients with retinopathy was significantly increased (p < 0.001), whereas SOD and CAT activities were decreased (p<0.001 and p<0.001, respectively) compared to those of controls. MDA concentrations rose while SOD and CAT activities fell with increasing severity of diabetic retinopathy, altough there was no significant difference in comprasion of the parameters mentioned above between the diabetic patients with and without retinopathy. Our results show that leukocytes in patients with type 2 diabetic retinopathy are affected by oxidative stress which might be contribute to pathogenesis of diabetic retinopathy. Prospective studies are needed to evaulate the relationship between the leukocyte antioxidants status and DR.

【 授权许可】

Unknown