Stereotactic radiosurgery of benign brain tumors in elderly patients: evaluation of outcome and toxicity

Radiation Oncology

Stefan Grau¹  Juman Tutunji²  Vera Weyer²  Harald Treuer²  Mauritius Hoevels²  Daniel Rueß²  Martin Kocher²  Maximilian I. Ruge²  Christian Baues³ 

[1] Department of Neurosurgery, Centre of Neurosurgery, Faculty of Medicine, University of Cologne;Department of Stereotaxy and Functional Neurosurgery, Centre of Neurosurgery, Medical Faculty and University Hospital Cologne, University of Cologne;Institute of Radiation Oncology, Faculty of Medicine, University of Cologne;

关键词: Radiosurgery;    Vestibular schwannoma;    Meningioma;    Elderly patients;   

DOI  :  10.1186/s13014-020-01714-0

来源: DOAJ

【 摘 要 】

Abstract Background Stereotactic radiosurgery (SRS) is widely accepted as a therapeutic option for meningiomas (M) and vestibular schwannomas (VS). However, data on outcome and toxicity in the elderly population have rarely been reported in detail. Methods All patients aged ≥ 65 years with M or VS who underwent single fraction SRS were included. Patient data were analyzed in terms of clinical tumor control and incidence of early and late treatment related complications, which were graded according to the Common Terminology Criteria for Adverse Events (CTCAE), Results We identified 245 patients with benign brain tumors (129 M and 116 VS, median tumor volume 2.9 ml, range 0.1–28). The median age was 71 years (range 65–86) and the mean follow-up times were 42 months (range 2–181). Tumors were irradiated with a median dose of 12.4 Gy. Actuarial clinical and radiological tumor control rates at 2, 5, and 10 years after SRS were 98%, 93%, and 88%, respectively. Recurrent tumors after previous treatment had a higher probability of post-radiosurgical progression (p < 0.001). Permanent toxicity (CTCAE I/II) were noted in 5.7%. No severe adverse events were observed during early and late follow up, although patients > 70 years had a slightly higher risk for toxicity (p = 0.027). The presence and extent of co-morbidities had no significant influence on local tumor control or toxicity. Conclusion SRS provides favorable tumor control with low risk for treatment-related severe complications. Thus, SRS should always be considered as treatment option for benign intracranial tumors (meningiomas, schwannomas), especially in the group of elderly patients.

【 授权许可】

Unknown