From Academia to the Market – Air-stable Ni(ii)/Josiphos Catalysts

CHIMIA

Achim Link¹  Florian Bächle¹  Anis Tlili²  Abderrahmane Amgoune² 

[1] Solvias AG, Römerpark 2, CH-4303 Kaiseraugst, Switzerland ;nstitute of Chemistry and Biochemistry (ICBMS–UMR CNRS 5246), Univ Lyon, Université Lyon 1, CNRS, CPE-Lyon, INSA, 43 Bd du 11 Novembre 1918, 69622 Villeurbanne, France;

关键词: acetone;    ammonia;    catalysis;    josiphos;    nickel;   

DOI  :  10.2533/chimia.2021.943

来源: DOAJ

【 摘 要 】

The design, synthesis, commercialization and application of air-stable Ni(II)/Josiphos complexes has been realized in a collaboration between Solvias and ICBMS (University Lyon 1). The Ni-complexes are utilized as versatile precatalysts for diverse cross-coupling reactions. Apart from being active in established C–C and C–N couplings at low catalyst loadings, the novel Ni-precatalysts enabled the development of the challenging monoarylation of ammonia, ammonia surrogates and even alkylammonium chlorides with aryl carbamates. Finally, the α-arylation of acetone with aryl chlorides, carbamates and pivalates was demonstrated using the Ni(II)/Josiphos precatalysts.