Preservation of Organs to Be Transplanted: An Essential Step in the Transplant Process

International Journal of Molecular Sciences

Sébastien Giraud¹  Maryne Lepoittevin¹  Raphael Thuillier¹  Thierry Hauet¹  Thomas Kerforne²  Lionel Badet³  Benoit Barrou³  Claire Goumard⁴  Sacha Mussot⁴  Petru Bucur⁴  Julien Branchereau⁴  Eric Savier⁴  Olaf Mercier⁴  Ephrem Salamé⁴  Pascal Battistella⁴ 

[1] Biochemistry Department, CHU Poitiers, 86021 Poitiers, France;Faculty of Medicine and Pharmacy, University of Poitiers, 86073 Poitiers, France;INSERM U1313, IRMETIST, 86021 Poitiers, France;Société Francophone de Transplantation et de l’Ecole Francophone pour le Prélèvement Multi-Organes, 75013 Paris, France;

关键词: kidney transplantation;    organ preservation;    temperature;    oxygen;   

DOI  :  10.3390/ijms23094989

来源: DOAJ

【 摘 要 】

Organ transplantation remains the treatment of last resort in case of failure of a vital organ (lung, liver, heart, intestine) or non-vital organ (essentially the kidney and pancreas) for which supplementary treatments exist. It remains the best alternative both in terms of quality-of-life and life expectancy for patients and of public health expenditure. Unfortunately, organ shortage remains a widespread issue, as on average only about 25% of patients waiting for an organ are transplanted each year. This situation has led to the consideration of recent donor populations (deceased by brain death with extended criteria or deceased after circulatory arrest). These organs are sensitive to the conditions of conservation during the ischemia phase, which have an impact on the graft’s short- and long-term fate. This evolution necessitates a more adapted management of organ donation and the optimization of preservation conditions. In this general review, the different aspects of preservation will be considered. Initially done by hypothermia with the help of specific solutions, preservation is evolving with oxygenated perfusion, in hypothermia or normothermia, aiming at maintaining tissue metabolism. Preservation time is also becoming a unique evaluation window to predict organ quality, allowing repair and/or optimization of recipient choice.

【 授权许可】

Unknown