More than Nutrition: Therapeutic Potential of Breast Milk-Derived Exosomes in Cancer

International Journal of Molecular Sciences

Wan-Hoon Kim¹  Chi Hwan Jeong¹  Hyeyoung Min¹  Ki-Uk Kim¹  Dae Yong Yi² 

[1] College of Pharmacy, Chung-Ang University, Seoul 06974, Korea;Department of Pediatrics, Chung-Ang University College of Medicine, Seoul 06974, Korea;

关键词: human milk;    nutrient;    microbiota;    exosomes;    microRNAs;    cancer;   

DOI  :  10.3390/ijms21197327

来源: DOAJ

【 摘 要 】

Human breast milk (HBM) is an irreplaceable source of nutrition for early infant growth and development. Breast-fed children are known to have a low prevalence and reduced risk of various diseases, such as necrotizing enterocolitis, gastroenteritis, acute lymphocytic leukemia, and acute myeloid leukemia. In recent years, HBM has been found to contain a microbiome, extracellular vesicles or exosomes, and microRNAs, as well as nutritional components and non-nutritional proteins, including immunoregulatory proteins, hormones, and growth factors. Especially, the milk-derived exosomes exert various physiological and therapeutic function in cell proliferation, inflammation, immunomodulation, and cancer, which are mainly attributed to their cargo molecules such as proteins and microRNAs. The exosomal miRNAs are protected from enzymatic digestion and acidic conditions, and play a critical role in immune regulation and cancer. In addition, the milk-derived exosomes are developed as drug carriers for delivering small molecules and siRNA to tumor sites. In this review, we examined the various components of HBM and their therapeutic potential, in particular of exosomes and microRNAs, towards cancer.

【 授权许可】

Unknown