Simplifying Diagnosis of Fetal Alcohol Syndrome Using Machine Learning Methods

Frontiers in Pediatrics

Eike Bormann¹  Moritz Blanck-Lubarsch²  Ariane Hohoff²  Reinhold Feldmann³  Dieter Dirksen⁴ 

[1] Department of Biostatistics and Clinical Research, University of Münster, Münster, Germany;Department of Orthodontics, University of Münster, Münster, Germany;Department of Pediatrics, University of Münster, Münster, Germany;Department of Prosthodontics and Biomaterials, University of Münster, Münster, Germany;

关键词: fetal alcohol spectrum disorder;    3D facial scans;    machine learning;    decision tree;    K-nearest neighbor;    support vector machine;   

DOI  :  10.3389/fped.2021.707566

来源: DOAJ

【 摘 要 】

IntroductionThe fetal alcohol spectrum disorder (FASD) is a complex and heterogeneous disorder, caused by gestational exposure to alcohol. Patients with fetal alcohol syndrome (FAS—most severe form of FASD) show abnormal facial features. The aim of our study was to use 3D- metric facial data of patients with FAS and identify machine learning methods, which could improve and objectify the diagnostic process.Material and MethodsFacial 3D scans of 30 children with FAS and 30 controls were analyzed. Skeletal, facial, dental and orthodontic parameters as collected in previous studies were used to evaluate their value for machine learning based diagnosis. Three machine learning methods, decision trees, support vector machine and k-nearest neighbors were tested with respect to their accuracy and clinical practicability.ResultsAll three of the above machine learning methods showed a high accuracy of 89.5%. The three predictors with the highest scores were: Midfacial length, palpebral fissure length of the right eye and nose breadth at sulcus nasi.ConclusionsWith the parameters right palpebral fissure length, midfacial length and nose breadth at sulcus nasi, machine learning was an efficient method for the objective and reliable detection of patients with FAS within our patient group. Of the three tested methods, decision trees would be the most helpful and easiest to apply method for everyday clinical and private practice.

【 授权许可】

Unknown