Biomarker and competing endogenous RNA potential of tumor-specific long noncoding RNA in chromophobe renal cell carcinoma

OncoTargets and Therapy

关键词: long non-coding RNA;    chromophobe renal cell carcinoma;    biomarker;    competing endogenous RNA network;   

DOI  :  

来源: DOAJ

【 摘 要 】

Hai-Tao He,1,2,* Mu Xu,1,* Ye Kuang,1 Xiao-Yun Han,1 Ming-Qi Wang,1 Qing Yang11Department of Pathogenobiology, 2Department of Cell Biology, College of Basic Medical Sciences, Jilin University, Changchun, People’s Republic of China*These authors contributed equally to this workBackground: Accumulating evidence suggests long noncoding RNAs (lncRNAs) play important roles in the initiation and progression of cancers. However, their functions in chromophobe renal cell carcinoma (chRCC) are not fully understood.Methods: We analyzed the expression profiles of lncRNA, microRNA, and protein-coding RNA, along with the clinical information of 59 primary chRCC patients collected from The Cancer Genome Atlas database to identify lncRNA biomarkers for prognosis. We also constructed an lncRNA–microRNA–mRNA coexpression network (competitive endogenous RNAs network) by bioinformational approach.Results: One hundred and forty-two lncRNAs were found to be differentially expressed between the cancer and normal tissues (fold change ≥1.5, P<0.001). Among them, 12 lncRNAs were also differentially expressed with the corresponding clinical characteristics (fold change ≥1.5, P<0.01). Besides, 7 lncRNAs (COL18A1-AS, BRE-AS1, SNHG7, TMEM51-AS1, C21orf62-AS1, LINC00336, and LINC00882) were identified to be significantly correlated with overall survival (log-rank P<0.05). A competitive endogenous RNA network in chRCC containing 16 lncRNAs, 18 miRNAs, and 168 protein-coding RNAs was constructed.Conclusion: Our results identified specific lncRNAs associated with chRCC progression and prognosis, and presented competing endogenous RNA potential of lncRNAs in the tumor.Keywords: long noncoding RNA, chromophobe renal cell carcinoma, biomarker, competing endogenous RNA network 

【 授权许可】

Unknown