Newcastle Disease Virus as a Vaccine Vector for SARS-CoV-2

Pathogens

Edris Shirvani¹  SibaK. Samal¹ 

[1] Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA;

关键词: SARS-CoV-2;    COVID-19;    coronavirus;    Newcastle disease virus (NDV);    vaccine;    viral vector and viral respiratory infection;   

DOI  :  10.3390/pathogens9080619

来源: DOAJ

【 摘 要 】

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in more than 16 million infections and more than 600,000 deaths worldwide. There is an urgent need to develop a safe and effective vaccine against SARS-CoV-2. Currently, several strategies are being pursued to develop a safe and effective SARS-CoV-2 vaccine. However, each vaccine strategy has distinct advantages and disadvantages. Therefore, it is important to evaluate multiple vaccine platforms to select the most efficient vaccine platform for SARS-CoV-2. In this regard, Newcastle disease virus (NDV), an avian virus, has several well-suited properties for development of a vector vaccine against SARS-CoV-2. Here, we elaborate on the idea of considering NDV as a vaccine vector for SARS-CoV-2.

【 授权许可】

Unknown