Exploring Bottom-Up Visual Processing and Visual Hallucinations in Parkinson's Disease With Dementia

Frontiers in Neurology

Rajnish Kumar Gupta¹  Daniel Collerton²  Charlotte Allan²  John-Paul Taylor²  Michael Firbank²  Mark R. Baker²  Alison Killen²  Lynn Rochester²  Nicholas Murphy⁴  Sara Graziadio⁵  Prabitha Urwyler⁶ 

[1] ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland;Faculty of Medical Sciences, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom;Gerontechnology and Rehabilitation Group, University of Bern, Bern, Switzerland;Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, United States;National Institute for Health Research Newcastle In Vitro Diagnostics Co-operative, Newcastle Upon Tyne Hospitals Foundation Trust, Newcastle upon Tyne, United Kingdom;University Neurorehabilitation Unit, Department of Neurology, Inselspital, Bern University Hospital, Bern, Switzerland;

关键词: visual processing;    Parkinson's disease dementia;    visual hallucination;    Lewy body;    visual evoked potential;   

DOI  :  10.3389/fneur.2020.579113

来源: DOAJ

【 摘 要 】

Visual hallucinations (VH) are a common symptom of Parkinson's disease with dementia (PDD), affecting up to 65% of cases. Integrative models of their etiology posit that a decline in executive control of the visuo-perceptual system is a primary mechanism of VH generation. The role of bottom-up processing in the manifestation of VH in this condition is still not clear although visual evoked potential (VEP) differences have been associated with VH at an earlier stage of PD. Here we compared the amplitude and latency pattern reversal VEPs in healthy controls (n = 21) and PDD patients (n = 34) with a range of VH severities. PDD patients showed increased N2 latency relative to controls, but no significant differences in VEP measures were found for patients reporting complex VH (CVH) (n = 17) compared to those without VH. Our VEP findings support previous reports of declining visual system physiology in PDD and some evidence of visual system differences between patients with and without VH. However, we did not replicate previous findings of a major relationships between the integrity of the visual pathway and VH.

【 授权许可】

Unknown